Neuroendocrine cancer with carcinoid syndrome
One of the major tools to evaluate this type of pathology is the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase.
They change related to the disease progression, regardless therapy. Some of the drugs that are used for NETs as somatostatin analogs for example octreotide might interfere with glucose metabolism.
NEUROENDOCRINE TUMORS: CHOOSING APPROPRIATE IMAGING METHODS
We analyzed in a retrospective study of 2 years the dynamic of the NET markers and the glycemia profile. Material and Methods. All the patients had at least one assay per year. The dose of octreotide varied from 20 to 50 mg, monthly. The fasting glucose insignificantly changed from baseline after 2 years.
Este o boala neoplazica avand ca punct de plecare celulele sistemului endocrin difuz SED. Tumorile carcinoide pot fi localizate oriunde la nivelul tubului digestiv, dar cel mai frecvent le gasim in jurul valvei ileocecale. Pot fi asimptomatice sau pot genera simptome obstructive.
No new case of diabetes was registered. One case of known diabetes needed insulin but interferon therapy was also added during this time period.
The chromogranin A had sustained high values for all the 9 cases, marking the disease progression. The neuron specific enolase significantly increased, and the serum serotonin as well as the 5HIIA neuroendocrine cancer with carcinoid syndrome much higher in 2 cases with aggressive carcinoid symptoms.
The NET markers and the glucose metabolism are most useful tools in the management of NETs, yet they are not correlated. Neuroendocrine tumors.
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METASTATIC CARCINOID TUMOR- ATYPICAL PRESENTATION
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