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Wart on eyelid nhs, Nuove politiche per l`innovazione nel settore delle scienze della vita

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Acestea modificã ireversibil integritatea structuralã a matricei dermice extracelulare. Ultravioletele de tip A au cel mai important rol în patogeneza îmbãtrânirii.

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Cuvinte cheie: fotoîmbãtrânire; radiaþii ultraviolete; sindrom Favre-Racouchot; lentigo solar. Intrat în redacþie: Acceptat: Summary Cutaneous photoaging appears as a consequence of prolonged exposure to ultraviolet UV radiations which modify irreversibly the structural integrity of the dermal extracellular matrix.

Type A UV virus hpv na lingua have wart on eyelid nhs most important role in aging pathogenesis. Key words: photoaging; ultraviolet radiations; Favre- Racouchot syndrome, solar lentigo.

Received: Accepted: Introducere Îmbãtrânirea pielii este rezultatul a douã procese diferite: îmbãtrânirea intrinsecã ºi cea extrinsecã [1,2].

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Îmbãtrânirea cutanatã intrinsecã se referã la modificãri ale pielii similare celor care afecteazã organele interne o datã cu înaintarea în wart on eyelid nhs ºi este influenþatã de contractarea muºchilor mimicii, de gravitaþie, de factori genetici ºi hormonali [1]. Aceasta va duce la atrofia ºi wart on eyelid nhs elasticitãþii cutanate, cauzate de scãderea numãrului de fibre elastice ºi de Introduction Skin aging is the result of two different processes: the intrinsic and the extrinsic aging [1,2].

The intrinsic skin aging refers to body changes affecting the entire skin, as well as other body organs, influenced by the contraction of mimic muscles, gravity, genetic and hormonal factors [1].

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This will lead to skin atrophy and loss of elasticity, due to decrease in number of elastic and collagen fibers and loss of repair capacity [1,3]. Imbãtrânirea cutanatã extrinsecã este denumitã fotoîmbãtrânire, întrucât este rezultatul expunerii prelungite la radiaþiile ultraviolete UV [1]. Aceste radiaþii promoveazã modificãri ireversibile helminth worms pictures nivelul integritãþii structurale a matricei dermice extracelulare, prin mecanisme care implicã stresul oxidativ ºi distrugeri mitocondriale [4].

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Principala consecinþã wart on eyelid nhs degradarea colagenului, stimulatã de acþiunea metaloproteinazelor ºi scãderea sintezei de colagen. Din punct de vedere histopatologic, aceste modificãri în derm ºi epiderm, însoþite de fibre elastice neregulate ºi mai puþin dense, sunt descrise ca elastozã solarã.

În plus, se pot observa atrofie epidermicã, joncþiune dermo-epidermicã aplatizatã, fibre de colagen ºi elastice degradate, cât ºi un material bazofilic în dermul papilar, a cãrui aranjare depinde de severitatea elasozei [1,4].

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Contributia UVA la fotoîmbatranire este mai mare, deoarece acest tip de ultraviolete pãtrunde pânã în dermul profund.

Discuþii Clinic, fotoîmbãtrânirea se caracterizeazã prin riduri, pigmentare neregulatã, lentigine solare, comedoane deschise, pierderea transluciditãþii ºi a elasticitãþii cutanate, teleangiectazii, keratoze actinice ºi piele xeroticã, de aspect gãlbui ºi poikilodermie [4,7,8].

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Fotoîmbãtrânirea se produce diferit la indivizi cu fototipuri cutanate diferite. The extrinsic skin aging is called photoaging because it is the result of prolonged UV radiation exposure [1]. UV radiation promotes irreversible changes in the structural integrity of dermal extracellular matrix through mechanisms related to oxygen reactive species and mitochondrial damage [4].

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The main result is collagen degradation, stimulated by the action of metalloproteinases and decrease in collagen production. Moreover, these changes, accompanied by irregular and less dense elastic fibers, are described histopathologically as solar elastosis, which affects both epidermis and dermis.

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Epidermal atrophy, flattened dermo-epidemal junction, damaged collagen and elastic fibers associated with basophilic material in the papillary dermis with different arrangement, according to the severity of the elastosis can be observed [1,4].

The contribution of UVA radiations to photoaging is more important because they can invade the deep dermis.

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Discussions Clinically, photoaging is characterized by wrinkles, irregular pigmentation, solar lentigines, open comedones, loss of elasticity and translucency, teleangiectasias, actinic keratoses and a yellowish, xerotic appearance of the skin and poikiloderma [4,7,8]. Photoaging occurs differently in individuals with different phototypes. Solar elastosis In solar elastosis, the skin chronically exposed to sunlight, especially the face, becomes yellow, thicker, with prominent wrinkles.

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Lesions 3 Fig. Pacient în vârstã de 62 ani cu sindrom Favre-Racouchot Fig.

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A year-old patient with Favre-Racouchot syndrome Fig. Leziuni similare în regiunea cervicalã posterioarã poartã denumirea de cutis rhomboidalis nuchae. Histopatologic, se observã elastozã dermicã proeminentã [11]. Sindromul Favre-Racouchot Cunoscut ca elastozã cutanatã nodularã cu chisturi ºi comedoane, presupune modificãri ale pielii în special în zona periorbitalã ºi se asociazã cu expunerea prelungitã la radiaþii wart on eyelid nhs ºi cu fumatul [12].

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Aceastã afecþiune a fost descrisã în rândul persoanelor cu vârstã de peste 50 ani, mai ales bãrbaþi caucazieni [13]. De asemenea, a fost raportatã ºi la persoane cu fototip închis sau tinere [12,13].

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Sindromul Favre-Racouchot se caracterizeazã prin multiple comedoane închise ºi deschise, papule, wart on eyelid nhs ºi noduli în regiunea temporalã ºi periocularã, cu o evoluþie prelungitã ºi distribuþie simetricã [12,13]. Au fost descrise leziuni unilaterale în cazul unor pacienþi trataþi cu radioterapie sau care s-au expus la soare cu o singurã parte a feþei [14,15].

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De asemenea, poate apãrea în zona cervicalã lateralã, pe pavilionul urechii ºi pe antebraþe [12]. Pielea adiacentã poate fi afectatã de elastozã solarã marcatã ºi poate affecting the posterior neck are known as cutis rhomboidalis nuchae.

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Histologically, it corresponds to dermal elastosis [11]. Favre-Racouchot Syndrome Favre-Racouchot syndrome FRSalso known as nodular cutaneous elastosis with cysts and comedones, refers to skin changes mostly affecting the periorbital area, associated with prolonged exposure to ultraviolet light and smoking [12].

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This entity has been described in people over 50 years old, mostly Caucasian men [13]. Cases involving dark-skin population or younger individuals have been reported as well [12,13].

Favre-Racouchot syndrome is characterized by multiple open and closed comedones, papules, cysts and nodules involving the temporal and periocular region, with a prolonged evolution and a symmetrical distribution [12,13].

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Unilateral lesions have also been described in patients treated with radiotherapy or with chronic unilateral sunlight exposure [14,15]. Other sun-exposed regions, such as lateral aspect of the neck, ears and forearms can also be involved [12].