Endocrine cancer prevalence. Role of nutrition in cancer
Background: Thyroid nodules were reported with high prevalence in acromegalic patients.
Patients and methods: 63 acromegalic patients 16 males and 47 femalesaged at diagnosis Median duration of acromegaly was 8 years. Thyroid ultrasound was performed. In suspected nodules, pathological examination either fine needle aspiration with cytology exam or pathology exam after thyroidectomy was performed.
Results: Median thyroid volume was Thyroid nodules were present in 52 patients Multiple thyroid nodules were found in 45 out of 52 cases Toxic multinodular goiter was prezent in 5 patients 7. Average maximum diameter of dominant nodule was 1.
Thyroid differentiated cancer endocrine cancer prevalence diagnosed in 6 patients 9. Histological type was papillary carcinoma: 3 macrocarcinomas and 3 microcarcinomas follicular variant of papillary carcinomas ; two microcarcinomas were multifocal.
Five patients with thyroid carcinomas underwent thyroidectomy; 4 patients two macrocarcinomas and two multifocal microcarcinomas also received radioiodine treatment.
Thyroid surgery is pending in one patient. Autoimmune thyroiditis was present in 4 patients 6.
Conclusion: Multinodular nontoxic thyroid disease was very frequent in our series of acromegalic patients. We also found an increased prevalence of differentiated thyroid carcinoma. Careful clinical thyroid examination, thyroid ultrasound endocrine cancer prevalence cytological exam were recommended in acromegalic patients.