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Human papillomavirus blood test. Prevenirea cancerului prin intermediul unor programe de screening

PCMC is more frequently found in males and it usually appears between the ages of 50 and Mendoza and Hedwig made the first contemporary description of this eyelid-located tumour.

The benefits are certain in some cases: life years gained for those with curable disease, avoidance of morbidity, reassurance that the disease is at a very early human papillomavirus blood test, avoiding expenses of treatment for advanced cancers and extra years of productivity. But screening tests also have disadvantages, so a balanced decision must be made, with the help of clinical randomized trials. In this article I will present the current methods for screening accepted for general population and particular screening reserved for persons at high risk. Although in the first case the benefit is proven, the use of these methods in practice varies largely due to lack of resources and well designed health programs.

Taking into consideration the rarity of this tumour, a diagnosis of certitude is difficult to establish until further investigations are made, in order to eliminate the primary malignant tumour with visceral location with mucine production that can metastasize at cutaneous level, as for example that of breast, gastrointestinal tract, lung, kidney, ovary, pancreas, or prostate.

The metastatic lesions that originate from the breast or colon are prone to mimic the cutaneous mucinous carcinoma 4. There is no specific clinical evidence for this type of tumour, as its appearance varies from one patient to another.

Prevenirea cancerului prin intermediul unor programe de screening

The first clinical impression is that of a cyst, basal cell carcinoma, keratoacantoma, nevus, apocrine hidrocystoma, another location primary tumour metastasis and in certain circumstances the clinical differentiation includes vascular lesions as those found in the Kaposi sarcoma 5. The patients describe a slow evolution, stretched over several years, of the lesion, completely asymptomatic.

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Occasional, the very old tumours or the very aggressive ones can invade the adjacent structures 6. The slow, benign evolution theory of this tumour is correlated with mucine production which is linked to its high celular differentiation grade.

Revista Romana de Medicina de Laborator

Moreover, the presence of big mucus accumulations can serve as physical barrier in tumour extension, compressing the tumour stroma, slowing the growth, inhibiting the DNA synthesis and decreasing the angiogenesis rate 8. Although the clinical presentation of PCMC is non-specific, the histopathological exam is pathognomonic.

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Usually, the tumour is well delimitated, with small accumulations or tubules human papillomavirus blood test epithelial cells which float in mucine. Mucine is separated by fine collagen fibres septa and is positive to PAS stain, mucicarmina, alcian blue at a pH of 2.

Prevenirea cancerului prin intermediul unor programe de screening

Mucine, same as sialomucine, was characterized as sialidase-labile. The cells are small, basaloid, vacuolated human papillomavirus blood test eosinophilic cytoplasm.

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The cellular pleomorfism and the 1. Primary mucinous carcinoma, J Dermatolog Surg Oncol Primary mucinous carcinoma of the skin with metastases to the lymph nodes.

Cancer prevention through screening programs

Am J Dermatopathol ; Carcinomas of sweat glands, report of 60 cases. Arch Pathol Lab Med human papillomavirus blood test Smith CC Metastazing carcinoma of the sweat-glands.

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Br J Surg43 Primary mucinous carcinoma of the skin: A population based study. Int J Dermatol. Further investigations are necessary in order to eliminate the skin metastasis 7,8.

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The immunohistochemistry exam can facilitate the differential diagnoisis. PCMC cells remain positive for CK 7 and negative for CK 20, the same occurs for the mucinous adenocarcinoma of the breast, but in the case of the mucinous colorectal adenocarcinoma CK 7 is negative and CK 20 is positive.

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This way, the absence of CK 20 excludes skin metastases originated from the mucinous colorectal adenocarcinoma. Another CK 7 positive and CK 20 negative tumours, as the adenocarcinoma of the lung or of the gallbladder, can also produce skin metastases.

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These can be excluded using systemic suplimentary investigations and another types of immunohistochemistry specific colorations 9. Because the skin metastases originating from breast and lung can express the p63 protein, the use of this expression remains controversial and so, further investigations are mandatory. Quereshi et al.

Меня, впрочем, куда сильнее заботило то, чтобы моя маленькая сага оказалась не столько исторически безупречной, сколько убедительной, но Коллитрэкс изучил ее и не обнаружил никаких ошибок. Вне всякого сомнения, она полностью совпадает со всем тем, что нам известно о Ярлане Зее и основании Диаспара.

In a complex analysis of the skin metastasis, Brownstein et al. The treatment of PCMC imposes local surgical excision. Because of the high local relapse rate, the proper excision with oncological safety margins at least 1 cm is recommended.

Dis Markers ;

The patients are informed that the periodical check-ups are human papillomavirus blood test great importance regarding the local recurrence or the appearance of locoregional lymphadenopathy. Conclusions PCMC is a human papillomavirus blood test malignant tumour that must be evaluated and treated correctly.

The certainty of diagnosis is achieved by histopathological exam, specific investigations for excluding a metastasis, followed by surgical treatment with oncologic safety margins.

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For the case report presented, we must underline that the local clinical exam was unspecific; the location of the tumour was extremely rare, with local invasion in sternal distal region, the anterior abdominal wall, peritoneum and mediastinum, since the diagnosis needed suplimentary investigations in order to establish the primary cutaneous mucinous adenocarcinoma.