Comprehensive staging in ovarian cancer

Cancer ovarian stage 1. Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian

The purpose of this paper is to quantify the in­ci­dence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic na­ture of this pathology.

Поразило его лишь то, что оказалось возможным вообще встретить кого бы то ни было в этой заброшенной башне, столь близко от границы неизведанного. Олвин повернулся спиной к миру зазеркалья и оказался лицом к лицу с непрошеным гостем.

Но, прежде чем он успел рот раскрыть, тот уже обратился к -- Насколько я понимаю, ты -- Олвин. Когда я обнаружил, что сюда кто-то приходит, мне следовало бы сразу же догадаться".

The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between 34 and 64 years old. Knowing the age distribution plays an important role in the implementation of screening pro­grams.

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All cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites. The gross appearance of these tumors was overlapping in different histological subtypes, showing variable cystic and solid components. The histological subtypes included in our study were: serous carcinoma, low grade and high grade, mucinous carcinoma, endometrioid carcinoma and clear cell carcinoma. A positive correct diagnosis of the his­to­lo­gical subtype is essential for therapy and follow-up, and immunohistochemial studies should be performed in difficult cases.

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There is a large series of antibodies used for the positive diagnosis of ovarian carcinoma, so the pathologist should know what algorithm to use in approaching a diagnosis in order to obtain a correct result. Scopul acestei lucrări este de a cuantifica incidența diferitelor tipuri histologice de tumori ovariene și de a demonstra importanța clinică a unui program eficient de screening, având în cancer ovarian stage 1 na­tura paucisimptomatică a acestei patologii.

Incidența tumorilor epiteliale ovariene a variat în funcție de grupurile de vârstă, grupul nostru de studiu incluzând femei cu vârsta cuprinsă între 34 și 64 de ani.

Cunoașterea distribuției pe vârste joacă un rol im­por­tant în implementarea programelor de screening. Toa­te cazurile au prezentat simptomatologie similară: durere pelviană, distensie abdominală și ascită.

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Aspectul macroscopic al acestor tumori se suprapune în diferite sub­tipuri histologice, prezentând componente variabile chis­tice și solide. Subtipurile histologice incluse în studiul nos­tru au fost carcinomul seros, de grad scăzut sau crescut, carcinomul mucinos, cancer ovarian stage 1 endometrioid și carcinomul cu celule cancer ovarian stage 1.

Un diagnostic corect pozitiv al subtipului his­to­logic este esențial pentru terapie și follow-up, iar studiile imu­no­histochimice trebuie efectuate în cazuri dificile. Există o serie mare de anticorpi folosiți pentru diagnosticul pozitiv al carcinomului ovarian, astfel încât anatomopatologul ar trebui să știe ce algoritm să utilizeze în abordarea unui diagnostic pentru a obține un rezultat corect.

Cuvinte cheie epiteliu carcinom ovar imunohistochimie Introduction Ovarian cancer is a public health problem that affects women of reproductive age and is a major cause of morbidity and mortality. Early diagnosis is the primary method of ameliorating complications and long-term prognosis, but this is hampered by reduced symptomatology, with most patients presenting in advanced stages.

Comprehensive staging in ovarian cancer

From tothe incidence rate and the mortality rate decreased by 0. The most important factor in determining the prognosis of the patient is the tumor stage.

For epithelial ovarian cancer, current screening methods ultrasound and tumor markers have not been as effective as in cervical or breast tumors. Ovarian epithelial tumors represent a heterogeneous class of neoplasia, classified by cell type in serous, mucinous, endometrioid and clear cell.

[Expression of CA-125 in ovarian cancer].

Because there are sarcoma cancer uterine benign equivalent tissues in the ovary, the mechanism of carcinogenesis was attributed initially to the ovarian epithelium mesotheliumbut recent studies have proposed that serous tumors are secondary tumors, derived from lesions of the fallopian tube fimbria, organismele parazite produc endometrioid tumor or clear cells tumors are secondary to ovarian endometriosis 4.

Ovarian epithelial tumors are classified according to the degree of nuclear atypia, cancer ovarian stage 1 proliferation and the presence or absence of stromal invasion, in benign, borderline and malignant conditions.

The borderline cancer ovarian stage 1 are called this cancer ovarian stage 1 because they present cytological and histological aspects that are intermediate between benign and malignant. Materials and method The purpose of this paper is to quantify the incidence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective scre­ening program, considering the paucisymptomatic nature of this pathology.

Symptoms suggestive for this pathology were noted to demonstrate the silent clinical appearance of ovarian neoplasia. Specimens were obtained from limited tumor excision, but also from oophorectomy and hysterectomy with cancer ovarian stage 1 anexectomy, formalin fixed and paraffin embedded, then stained with Hematoxylin-Eosin.

Knowing that the diagnosis age for a significant proportion of patients is above 65 years old, for a proper therapeutic conduct and in order to avoid treatment interruptions caused by toxicity, it was attempted the adjustment of the initial protocole. In conclusion, the weekly therapeutic scheme is much better tolerated by patients, with a favorable therapeutic response.

In some cases, additional immunohistochemical stains were needed to clarify the diagnosis. Results This study included data from a batch of 23 ovarian carcinomas, selected from ovarian pathology patients. The incidence of ovarian cancer ovarian stage 1 tumors varies across age groups, our study group including women aged between 34 and 64 years old.

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Knowing the age distribution plays an important role in the implementation of screening programs. All cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites in two cases. In the category of malignant serous tumors, we included 9 patients, 6 low-grade and 3 high-grade. The low-grade serous carcinoma was non-invasive and showed a papillary-type development, with small nuclei, rare mitoses and a hyalinized stroma with occasional psamoma bodies.

Immunohistochemical assays showed positivity to CK7 and ER.

Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian

Figure 1. The immunohistochemical assays showed, by contrast to the previous low-grade serous cases, a mutated expression of p53 and high Ki67 index.

The pattern of p53 immunosay is very important and the result should cancer ovarian stage 1 to the presence or absence of a mutation.

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