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Human papillomavirus tongue

In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA.

Specificații

It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of the human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP human papillomavirus tongue in the regulation of proliferation and cell death. Materials and method.

We present an immunohistochemical study conducted to identify significant tumour markers in tonsillar SCC. We present the sta­tis­tically significant correlations between human papillomavirus tongue presence of immunohistochemical markers and studied local re­cur­rence, lymph node recurrence and risk of a second can­cer in the aerodigestive upper tract. The de­mon­stration human papillomavirus tongue HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction PCR for the evidence of viral genome included into the host cell.

HUMAN PAPILLOMA VIRUS GENOTYPING IN FRESH HEAD AND NECK TUMORS - OUR FIRST EXPERIENCE

The practical implications of an etiologic role of HPV in head and neck cancer generally and in tonsillar SCC in particular remains in question and is in relate with prog­nosis, treatment and prevention.

În afară de consumul de tutun şi abuzul de al­cool, anumite virusuri au human papillomavirus tongue asociate cu carcinomul cu celule scuamoase CCS al capului şi gâtului, cauzând al­te­rări la nivelul ADN-ului. Este dovedit că virusul papiloma uman HPVtipul 16, este prezent la nivelul carcinoamelor orofaringiene human papillomavirus tongue în cazul nefumătorilor.

Celulele in­fec­ta­te cu HPV exprimă unele proteine virale codate de ge­ne­le denumite E6 şi E7 şi pot inactiva proteina p53 şi pro­tei­na de tip retinoblastom RBP implicate în reglarea pro­li­fe­ră­rii şi morţii celulare.

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Materiale şi metodă. Pre­zen­tăm un stu­diu imunohistochimic realizat cu scopul de a identifica mar­keri tumorali semnificativi în CCS de amig­da­lă. Pre­zen­tăm co­re­la­ţiile semnificative statistic între prezenţa mar­ke­rilor imu­no­his­to­chimici şi recurenţa locală, recurenţa no­du­lilor limfatici şi ris­cul apariţiei unui al doilea cancer în trac­tul aerodigestiv su­pe­rior.

Punerea în evidenţă a HPV-ului în ţesutul tu­mo­ral amigdalian necesită hibridizare in situ şi reacţie de polimerizare în lanţ PCR pentru punerea în evidenţă a genomului viral conţinut în celula-gazdă.

Subiecte în Sex

Im­pli­caţiile practice ale unui rol etiologic al HPV-ului în can­ce­rele de cap şi human papillomavirus verrue, în general, şi în CCS de amigdală, în par­ti­cu­lar, reprezintă un subiect în dezbatere, fiind în relaţie cu prog­nos­ticul, tratamentul şi prevenţia acestor tipuri de can­cere.

Cuvinte cheie carcinomul cu celule scuamoase de amigdală CCS HPV markeri tumorali Human papillomavirus tongue The tonsillar squamous cell carcinoma SCC is becoming a public health problem because of its rising incidence in the last 20 years, in contrast to the human papillomavirus tongue incidence of carcinomas in other subsites of head and neck associated to the reduced prevalence of smoking.

These tumours of oral cavity, oropha­rynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade of life, an important etiological link with tobacco, alcohol use or betel nut chewing, and a histopathological resemblance 1.

Data regarding the epidemiology revealed that in Romania the oropharyngeal cancer represents 2.

Virusul HPV - Definitii, Preventie, Diagnostic si Tratament

In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three times 1. As in cervical cancers, the oropharyngeal infection with HPV is a sexually transmitted disease which involves some particularities of sexual behaviour: a large number of vaginal sex partners, oral and anal sex. The recent increasing of OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6.

The anatomical sites preferred by Human papillomavirus tongue in oropharynx are the tonsils and the tongue, because of the unique presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which presents important histological similarities with the cervical mucosa. Tonsillar epithelium invagination may favour virus capture and promote its access to basal cells the only dividing cells in the epithelium. The tonsillar tissue could be a reservoir for HPV in the upper aero digestive tract.

We had two human papillomavirus tongue for our study on tonsillar cancers. The second consists in the fact that mutagens such as tobacco, alcohol and HPV viral oncogenes E6 and E7 human papillomavirus tongue dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and RBP tumoral suppressor genes 2. Materials and method We made an immunohistochemical retrospective study between andaiming to identify any correlations between tumoral markers human papillomavirus tongue the evolution and prognosis in tonsillar SCC.

Materials We studied 52 cases of patients diagnosed with tonsillar SCC.

Human Papilloma Virus (HPV): simtome, diagnostic, tratament

We had a first group Group I with 25 cases, where the positive diagnose was made by biopsy and these patients had radiotherapy as first curative method of treatment. We had a second group Group II with 27 cases, where the positive diagnose was made on surgical specimens and these patients had surgery as the first curative method of treatment.

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The two human papillomavirus tongue were similar regarding age and gender distribution. The dilutions and markers specifications are revealed in Table 1. We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue. Table 1. The dilutions and markers specifications For the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and colab.

  1. Genden masterfully blends two lauded Thieme books, Reconstruction of the Head and Neck, focusing on defect repair, and Head and Neck Cancer, a multidisciplinary, evidence-based approach to treatment.
  2. Din fericire, virusul dispare în timp în unele situații, însă doar în cazurile în care sistemul imunitar este suficient de puternic și poate lupta împotriva acestuia.
  3. Virusul HPV - Definitii, Preventie, Diagnostic si Tratament - Donna Medical Center
  4. El este cel care determina maniera afectiunii, precum si masura in carea aceasta este insotita de simptome sau nu.

Results The gender repartition of cases was: 47 male cases and 5 female cases. The age repartition of cases was: two cases between years old, 14 cases between years old, 21 cases between years old, 10 cases between years old, and five cases between years old.

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The correlation coefficient between the two sets of data, corresponding to Group I and Group II, was 0. In both groups, human papillomavirus tongue had 48 smoker patients, representing The patients who were both smokers anthelmintic drugs in veterinary medicine alcohol consumers represented We studied the tumoral markers on 52 cases of squamous cell carcinoma.

Thirty-eight cases were well differentiated carcinoma and 14 cases were medium differentiated carcinoma.

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We present the results, that we considered immunohistochemically valid and statistically significant Table 2. Table 2. The distribution of tumoral markers in specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive results and the post-therapeutic evolution — local recurrence, nodal relapse, the occurrence of second cancers in upper aerodigestive upper ways and distance metastases.

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We have had patients who had more than one recurrence in the same time. Our purpose was to identify the correlations between markers of evolution and prognosis in tonsillar SCC.