Papillomavirus tonsil cancer. Încărcat de

Head and Neck Cancer: Management and Reconstruction

In addition to papillomavirus tonsil cancer and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of the human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express papillomavirus tonsil cancer viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP involved in the regulation of proliferation and cell death.

Cancerul amigdalian Autor: Stanca Alina Elenapublicat la Cancerul amigdalian face parte din cancerele capului şi gâtului şi este cel mai frecvent tip de tumoră malignă a orofaringelui. Punctul de plecare al acestei afecţiuni îl reprezintă inelul lui Waldeyer, format din amigdalele faringiane, amigdalele tubare, amigdalele palatine şi amigdalele linguale, toate cu rol în apărarea organismului de agenţii infecţioşi. Dintre acestea, amigdalele palatine sunt cel mai frecvent sediul unui cancer amigdalian. Incidenţa acestei afecţiuni variază de la ţară la ţară sau chiar în interiorul aceleiaşi populaţii în limite largi.

Materials and method. We present an immunohistochemical study conducted to identify significant tumour markers in tonsillar SCC.

We present the sta­tis­tically significant correlations between the presence of immunohistochemical markers and studied local re­cur­rence, lymph node recurrence and risk of a second can­cer in the aerodigestive upper tract. The de­mon­stration of HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction PCR for the evidence of viral genome included into the host cell.

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The practical implications of an etiologic role of HPV in head and neck cancer generally and in tonsillar SCC in particular remains in question and is in relate with prog­nosis, treatment and prevention. În afară de consumul de tutun şi abuzul de al­cool, anumite virusuri au fost asociate cu carcinomul cu celule scuamoase CCS al capului şi gâtului, cauzând al­te­rări la nivelul ADN-ului.

Este dovedit că virusul papiloma uman HPVtipul 16, este prezent la nivelul carcinoamelor orofaringiene inclusiv în cazul nefumătorilor. Celulele in­fec­ta­te cu HPV exprimă unele proteine virale codate de ge­ne­le denumite E6 şi E7 şi pot inactiva proteina p53 şi pro­tei­na de tip retinoblastom RBP implicate în reglarea pro­li­fe­ră­rii şi morţii celulare.

Materiale şi metodă.

Pre­zen­tăm un stu­diu imunohistochimic realizat cu scopul de a identifica mar­keri tumorali semnificativi în CCS de amig­da­lă. Pre­zen­tăm co­re­la­ţiile semnificative statistic între prezenţa mar­ke­rilor imu­no­his­to­chimici şi recurenţa locală, recurenţa no­du­lilor limfatici şi ris­cul apariţiei unui al doilea cancer în trac­tul aerodigestiv su­pe­rior. Punerea în evidenţă a HPV-ului în papillomavirus tonsil cancer tu­mo­ral amigdalian necesită hibridizare in situ şi reacţie de polimerizare în lanţ PCR pentru punerea în evidenţă a genomului viral conţinut în celula-gazdă.

Im­pli­caţiile practice ale unui rol etiologic al HPV-ului în can­ce­rele de cap papillomavirus tonsil cancer gât, în general, şi în CCS de amigdală, în par­ti­cu­lar, reprezintă un subiect în dezbatere, fiind în relaţie cu prog­nos­ticul, tratamentul şi prevenţia acestor tipuri de can­cere.

Cuvinte cheie carcinomul cu celule scuamoase de amigdală CCS HPV markeri tumorali Introduction The tonsillar squamous cell carcinoma SCC is becoming a public health problem because of its rising incidence in the last 20 years, in contrast to the decreasing incidence of carcinomas in other subsites of head and neck associated to the reduced prevalence of smoking. These tumours of oral cavity, oropha­rynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade papillomavirus tonsil cancer life, an important etiological link with tobacco, alcohol use or betel nut chewing, and a histopathological resemblance papillomavirus tonsil cancer.

Data regarding the epidemiology papillomavirus tonsil cancer that in Romania the oropharyngeal cancer represents 2.

Traducerea «papillomavirus» în 25 de limbi

In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three times 1. As in cervical cancers, the oropharyngeal infection with HPV is a sexually transmitted disease which involves some particularities of sexual behaviour: a large papillomavirus tonsil cancer of vaginal sex partners, oral and anal sex. The recent increasing of OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6.

The anatomical sites preferred by HPV in oropharynx are the tonsils and the tongue, because of the unique presence of transitional mucosa in oropharynx papillomavirus tonsil cancer particular in tonsillar tissue, which presents important histological similarities with the cervical mucosa.

Tonsillar epithelium invagination may favour virus capture and promote its access to basal cells the only dividing cells in the epithelium. The tonsillar tissue could be a reservoir for HPV in the upper aero digestive tract.

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2. Aim: To implement the HPV genotyping method of fresh head and neck cancer samples in our laboratory.
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4. Head and Neck Cancer: Management and Reconstruction, ORL - asspub.ro
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We had two premises for our study on tonsillar cancers. The second consists in the fact that mutagens such as tobacco, alcohol and HPV viral oncogenes E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and RBP tumoral suppressor genes 2.

According to some recent studies, the HPV infection may also increase the risk of cardiovascular diseases. Strains of HPV 16 and 18 are strains with a high cancer risk, known to cause almost all cases of cervical cancer while also increasing the risk to develop oropharyngeal cancer[3]. Structura HPV women. Fig 1.

Materials and method We made an immunohistochemical retrospective study between and cancer vezica urinara speranta de viata, aiming to identify any correlations between tumoral markers and the evolution and prognosis in tonsillar SCC. Materials We studied 52 cases of patients diagnosed with tonsillar SCC.

Cauze şi factori de risc

We had a first group Group I with 25 cases, where the positive diagnose was made by biopsy and these patients had radiotherapy as first curative method of treatment.

We had a second group Group II with 27 cases, where the positive diagnose was made on surgical specimens and these patients had surgery as the first curative method of treatment.

The two groups were similar regarding age and gender distribution. The dilutions and markers specifications are revealed in Table 1.

Diagnostic

We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue. Table 1. The dilutions and markers specifications For the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and colab. Results The gender repartition of cases was: 47 male cases and 5 female cases. The age repartition of cases was: two cases papillomavirus tonsil cancer years old, 14 cases between years old, 21 cases between years old, 10 cases between years old, and five cases between years old.

The correlation coefficient between the two sets of data, corresponding to Group I and Group II, was 0.