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Human papillomavirus vaccine in saudi arabia

human papillomavirus vaccine in saudi arabia

Histologic imaginea este de carcinom epidermoid in situ, papuloza bowenoidã putând fi consideratã o neoplazie intraepitelialã. În etiologia bolii sunt incriminate papiloma virusurile umane cu risc crescut HPV 16, human papillomavirus vaccine in saudi arabia, 31, 33, 39 dar evoluþia spontanã a bolii este spre regresie. Tratamentul papulozei bowenoide constã în distrugerea medicalã sau chirurgicalã a leziunilor.

Cuvinte cheie: papuloza bowenoidã, papiloma virusuri, neoplazie intraepitelialã. The histological appearance is that of epidermoid carcinoma in situ, therefore Bowenoid papulosis human papillomavirus vaccine in saudi arabia be considered an intraepithelial neoplasia.

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Although high-risk human papillomaviruses HPV 16, 18, 31, 33, 39 are responsible for its etiology, most lesions are benign and regress spontaneously. The treatment of Bowenoid papulosis consists in the medical or surgical removal of the lesions.

Indicatia se bazeaza pe datele clinice generate la fete si femei cu varste intre 10 si 25 de ani. Datele, provenind din studiile clinice care au inrolat aproape 30 de femei, au demonstrat un profil excelent de eficacitate si imunogenitate pentru Cervarix. In Australia, Cervarix poate fi utilizat pentru vaccinarea femeilor cu varste cuprinse intre 10 si 45 de ani. Ulterior, au fost acordate licente si pe alte piete internationale.

The images accompanying the text show typical Bowenoid papulosis in a male patient and a rare case of diffuse, erythroleukoplastic, pigmented Bowenoid papulosis in a female patient plus the corresponding histological image courtesy of Professor A. Oanþã, MD, PhD.

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Key words: Bowenoid papulosis, papillomaviruses, intraepithelial neoplasia Denumirea de papulozã bowenoidã PB a fost introdusã de Wade ºi Ackerman în pentru descrierea de leziuni clinice ºi evolutive asemãnãtoare condiloamelor acuminate dar având aspect histologic de neoplazie intraepitelialã bowenianã NIEidentic cu al bolii Bowen [1].

Iniþial afecþiunea a fost cunoscutã ºi sub alte denumiri precum boala Bowen BB multicentricã [2], papule pigmentate ale penisului [3], acantoza cu displazie, displazie bowenianã, atipie vulvarã reversibilã [4], carcinom in situ vulvar.

Denumirea de PB a fost The name Bowenoid papulosis BP was first introduced by Wade and Ackerman in to describe clinical lesions similar to acuminate condyloma but with the histological appearance of intraepithelial neoplasia IENidentical to that of Bowen s disease [1].

The disease was initially known under various names such as multicentric Bowen s disease BD [2], pigmented penis papules [3] acanthosis with dysplasia, Bowenoid dysplasia, reversible vulvar atypia [4] or vulvar carcinoma in situ.

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Epidemiologie Nu existã studii epidemiologice privind PB, dar leziunile apar mai frecvent la subiecþii imunodeprimaþi îndeosebi la pacienþii HIV pozitiv.

Aspect clinic Papuloza bowenoidã afecteazã îndeosebi pacienþi tineri, pruritul fiind simptomul revelator într-o treime din cazuri. Leziunea elementarã este o maculã sau o papulã planã sau mamelonatã, uneori verucoasã, de culoare brunã fig. Leziunile sunt în general multiple, dispuse simetric, cancerul cauzele aparitiei dar uneori confluate în placarde cu pãstrarea individualitãþii, localizate la nivelul organelor genitale externe.

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La femei ºi la pacienþii HIV pozitiv leziunile se pot extinde pe regiunea perinealã, perianalã sau chiar în canalul anal. În afara acestui aspect clasic, PB poate lua aspecte polimorfe de papule plane roºii sau violacee localizate pe versantul mucos al organelor genitale externe, de papule translucide pe gland, de papule veruciforme fãrã caracter acuminat sau de papule hemisferice asemãnãtoare leziunilor de moluscum contagiosum.

La femei poate exista o formã difuzã, în pânzã, eritroleucoplazicã ºi pigmentatã afectând vulva în totalitate fig.

human papillomavirus vaccine in saudi arabia

Aceste leziuni extinse nu prezintã tendinþã de remitere ºi excepþional pot deveni invazive. NIE se caracterizeazã histologic prin hiperplazie epitelialã mai mult sau mai puþin marcatã, un strat cornos adesea parakeratozic, o maturare anormalã a keratinocitelor care pãstreazã un aspect bazofil evident pe lesions as well as their atypical histological appearance.

Epidemiology There are no epidemiological human papillomavirus vaccine in saudi arabia on BP; however, the lesions occur more frequently in immunocompromised subjects, especially HIVpositive patients. Clinical aspect Bowenoid papulosis mainly affects young individuals, itching being the telling symptom in one third of the cases. The primary lesion is either a macula or a plain or mamillated papule, sometimes verrucous and brown-colored Fig.

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The lesions are usually multiple, symmetrical, isolated or coalesced into individual plaques located on the external genitalia. In female and HIV-positive patients, the lesions may spread to the perineal and perianal region or even the anal canal. Besides this classical appearance, BP may present as polymorphic red or purple flat papules located on the mucous membranes of the external genitalia, translucent papules on the glans penis, non-acuminate verrucous papules or hemispherical papules resembling moluscum contagiosum.

In women, a diffuse, cobweb, erythroleukoplastic and pigmented form may completely affect the vulva Fig. Such extended lesions are not prone to remission and may exceptionally become invasive. Histologically, IEN is characterized by more or less human papillomavirus vaccine in saudi arabia epithelial hyperplasia, a corneous layer usually displaying parakeratosis and an abnormal maturation of keratinocytes that maintain a noticeable basophilic appearance on the entire height of the epithelium Human papillomavirus vaccine in saudi arabia.

The following Figura 1. Papule pigmentate la nivelul regiunii pubiene ºi tecii penisului. Figure 1.

PAPULOZA BOWENOIDÃ BOWENOID PAPULOSIS

Pigmented papules in the pubic area and penis sheath. Figura 2. Papuloza bowenianã forma difuzã în pânzã a mucoasei vulvare.

Human Papillomavirus (HPV) Statistics - Did You Know?

Figure 2. Bowenoid papulosis diffuse form in cloth vulvar mucosa.

PAPULOZA BOWENOIDÃ BOWENOID PAPULOSIS - PDF Free Download

Figura 3. Aspect histopatologic al papulozei boweniene. Figure 3.

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Histopathological aspects of papulozei boweniene. La aceste imagini se asociazã dezorganizarea arhitecturalã, atipii citonucleare severe, cu prezenþa uneori de mitoze ºi celule diskeratozice prezente pe toatã suprafaþa epiteliului precum ºi koilocite. Displaziile severe din PB ºi BB sunt prezente pe toatã înãlþimea epidermului, deosebindu-se de displaziile bazale din lichenul scleros atipii citonucleare limitate la straturile bazal ºi anemie hipocroma also be observed: architectural disorganization, severe cytonuclear atypia, possible mitosis and dyskeratosis on the entire surface of human papillomavirus vaccine in saudi arabia epithelium as well as koilocytes.

Severe dysplasia in BP and BD occurs on the entire height of the epidermis thus differentiating itself from the basal dysplasia in lichen sclerosus cytonuclear atypia limited to the basal and suprabasal layers.

HPV oncogene sunt regãsite ºi în boala Bowen ºi în câteva cancere vulvare ºi ale penisului precum ºi în neoplaziile intraepiteliale ºi invazive cervicale [6, 7] sugerând cã modificãrile histologice ale acestor afecþiuni corespund unei etiologii comune tabelul I.