Hereditary Cancer Syndromes: "The Angelina Effect"

Cancer being genetic

Subscribe What is EndoPredict? EndoPredict is a 2nd generation multi-gene breast cancer recurrence test for pre- or postmenopausal women newly diagnosed with early-stage breast cancer. Created for the purpose of highly accurate assessment of 5 to year risk of distant recurrence of the disease EndoPredict combines into an unique indicator EPClin score gene expression with clinically pathological cancer being genetic providing outstanding prognostic performance that will ensure the healthcare professional that chemotherapy is or is not required to accompany endocrine treatment.

Special Report: Fast machines, genes and the future of medicine

Considering these aspects, realizing that the cancer has a high or low risk of recurrence can help patients and doctors decide if chemotherapy after surgery is or is not necessary to accompany endocrine therapy. What DNA sample is required to perform the test?

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EndoPredict requires a simple tumor tissue sample that is customarily prepared for the pathology exam upon surgical tumor removal. The latest diagnostic and prognostic technology allows healthcare specialists to determine suitable treatment procedures based completely on the needs and DNA of the patient.

Prevenirea cancerului prin intermediul unor programe de screening

Therefore, the decision of breast cancer therapy increasingly depends on your own mix of gene markers. In this context, EndoPredict reveals critical information about the way that a tumor is likely to react at a genetic level. Why is EndoPredict relevant?

BRCA Genes and Breast Cancer

At the same time it can convince those at low risk of recurrence that chemotherapy is not mandatory. Thus, the test is practically an important step ahead towards the goal of truly customized care, helping breast cancer therapists to avoid both over- and under treatment of breast cancer with chemotherapy.

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When do breast cancer metastases occur? Breast cancer metastases mostly happen within the first three years following the initial diagnosis.

TR Hereditary Cancer Syndromes: "The Angelina Effect" Angelina Jolie's announcement triggered an increase in the number of people in high risk being screened and this is a very important step so they can minimize the chances of the disease cancer being genetic. Since the year that the famous actor announced her prophylactic surgery the referrals for genetic testing and counselling for hereditary breast cancer were grown dramatically.

One of the objectives of EndoPredict test is to calculate the tendency for cancer recurrence or late metastases. What is the best treatment to lower the risk of developing a recurrence of the breast cancer?

And he was surprised by what he learned. And so it goes in the fledgling genome field. James Lupski of the Baylor College of Medicine in Houston studied his own entire DNA map and sequenced the genomes of family members — including his deceased grandfather — to diagnose the mutation causing his rare genetic nerve disease, called Charcot-Marie-Tooth syndrome. Still, Collins describes this as low-hanging fruit. He says the hard work is only just beginning.

For early and locally advanced breast cancer the first clinical step is, of course, to surgically remove the tumor. The next step requires a more complex decision.

The benefits are certain in some cases: life years gained for those with curable disease, avoidance of morbidity, reassurance that the disease is at a very early stage, avoiding expenses of treatment for advanced cancers and extra years of productivity. But cancer being genetic tests also have disadvantages, so a balanced decision must be made, with the help of clinical randomized trials.

Around half of the intermediate patients currently receive unnecessary chemotherapy, which is very stressful for the organism, has serious side-effects, is toxic by nature and has a significant impact on mortality. that reason, it is very important to be able cancer being genetic identify the patients who would not cancer being genetic benefit from chemotherapy in any case and to be able to provide a more focused care, including systemic endocrine therapy, instead.

EndoPredict  manages to cancer being genetic this happen.

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The result? The ones who would not adequately benefit from chemotherapy can be spared from this treatment and its correlated side-effects.

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How does the test work? Performed on preserved breast tumor tissue that was removed during the initial biopsy or surgery, the EndoPredict test analyzes the activity of rigorously selected prolipherative and cancer being genetic genes in breast cancer cells.

Human cytochromes P450: evolution and cDNA-directed expression.

These genes are linked to the possibility that the cancer will come cancer being genetic in a different part of the body within 15 years after initial diagnosis.

The test includes the size of the breast tumor and whether or not the cancer being genetic is in the lymph nodes when calculating the risk score.

  1. Virus del papiloma humano caracteristicas sintomas y tratamiento
  2. Selected References These references are in PubMed.
  3. Hereditary Cancer Syndromes: "The Angelina Effect"
  4. Qka eshte human papillomavirus
  5. Элвин стоял молча, несколько ошеломленный.

The scores are recognized either low-risk or high-risk: an EPclin Risk Score higher than 3. With the help of our partner physicians, experts in genetic counseling in breast cancer, you will find out the benefits of the EndoPredict test, understand the clinical results and make the right decisions for your future health.

Fill this form to get in touch with a doctor for a clinic consultation and testing.

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